Eupalinolide O

• CAT Number: I044824
• CAS Number: 2170228-67-6
• Molecular Formula: C22H26O8
• Molecular Weight: 418.44
• Purity: ≥95%
• Synonyms: [(3aR,4R,6E,9R,10E,11aR)-9-acetyloxy-6-formyl-10-methyl-3-methylidene-2-oxo-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-4-yl] (E)-4-hydroxy-2-methylbut-2-enoate
• IUPAC Name: [(3aR,4R,6E,9S,10E,11aR)-9-acetyloxy-6-formyl-10-methyl-3-methylidene-2-oxo-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-4-yl] (E)-4-hydroxy-2-methylbut-2-enoate
• InChI: InChI=1S/C22H26O8/c1-12(7-8-23)21(26)29-19-10-16(11-24)5-6-17(28-15(4)25)13(2)9-18-20(19)14(3)22(27)30-18/h5,7,9,11,17-20,23H,3,6,8,10H2,1-2,4H3/b12-7+,13-9+,16-5+/t17-,18+,19+,20-/m0/s1
• InChIKey: MAIWERGSXNNKMK-KJXUJBMCSA-N
• SMILES: C/C/1=C\[C@@H]2[C@@H]([C@@H](C/C(=C\C[C@@H]1OC(=O)C)/C=O)OC(=O)/C(=C/CO)/C)C(=C)C(=O)O2

Eupalinolide O（Cat No.:I044824）is a sesquiterpene lactone isolated from the medicinal plant Eupatorium lindleyanum, traditionally used in Chinese medicine for respiratory and inflammatory conditions. It features a germacranolide skeleton with reactive α-methylene-γ-lactone and epoxide moieties, which contribute to its potent biological activities. Eupalinolide O has demonstrated significant anti-inflammatory and anticancer properties, primarily through the inhibition of NF-κB signaling and induction of apoptosis in cancer cells. Its ability to modulate key cellular pathways makes it a promising candidate for drug development targeting inflammation-related diseases and malignancies.