Etiocholanolone-d5

• CAT Number: I045594
• CAS Number: 1620102-33-1
• Molecular Formula: C19H25D5O2
• Molecular Weight: 295.47
• Purity: ≥95%
• Synonyms: (3R,5R,8R,9S,10S,13S,14S)-2,2,3,4,4-pentadeuterio-3-hydroxy-10,13-dimethyl-5,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-one
• InChI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13-,14+,15+,16+,18+,19+/m1/s1/i7D2,11D2,13D
• InChIKey: QGXBDMJGAMFCBF-JHABVYBQSA-N
• SMILES: CC12CCC(CC1CCC3C2CCC4(C3CCC4=O)C)O

Etiocholanolone-d5 (Cat No.: I045594) is a stable isotope-labeled analog of etiocholanolone, an endogenous androgen metabolite derived from testosterone and androstenedione. Incorporating five deuterium atoms, it is commonly used as an internal standard in liquid chromatography–mass spectrometry (LC-MS/MS) for accurate quantification of steroid hormones in biological samples. Etiocholanolone itself has immunomodulatory and pyrogenic properties, influencing inflammatory responses and fever. The deuterated form, Etiocholanolone-d5, is a valuable tool in endocrinology, clinical diagnostics, and pharmacokinetic research focused on steroid metabolism and biomarker profiling.

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Ping Li,et al. Natural and Enantiomeric Etiocholanolone Interact With Distinct Sites on the Rat alpha1beta2gamma2L GABAA Receptor. Mol Pharmacol. 2007 Jun;71(6):1582-90.
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[3]. Dorota Zolkowska, et al. Anticonvulsant Potencies of the Enantiomers of the Neurosteroids Androsterone and Etiocholanolone Exceed Those of the Natural Forms. Psychopharmacology (Berl). 2014 Sep;231(17):3325-32.
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