Etidronate - CAS 2809-21-4

Etidronate (CAT: A000482) is a non-aminobisphosphonate compound with versatile pharmacological properties. It exhibits protein tyrosine phosphatase (PTP) inhibitory activity, making it valuable for treating Paget’s disease and preventing heterotopic ossification. The mechanism of action includes direct inhibition of osteoclastic bone-resorbing activity, induction of apoptosis, and disruption of actin rings in osteoclasts. In experimental studies, Etidronate has demonstrated efficacy in suppressing mechanical allodynia and preserving bone mineral density in arthritic animal models. Its multifaceted activities contribute to its relevance in pharmaceutical and medical research, particularly in bone health and pain management studies.

Catalog Number: A000482

CAS Number: 2809-21-4

PubChem Substance ID:355038767

Molecular Formula: C2H8O7P2

Molecular Weight:206.03

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

SynonymsNA

Property

Molecular Formula: C2H8O7P2
Molecular Weight206.03
Target:protein tyrosine phosphatase
Purity≥95%
Storage3 years -20C powder
Overview of Clinical Research<span style=”color:#000000;”><span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-size:12px;”>Etidronate is a bone resorption factor inhibitor and a DNA synthesis inhibitor.&nbsp;<span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>The phase I trial in Bone metastases in Russia (IV) (NCT02673060) is ongoing.</span></span></span></span>

Computed Descriptor

IUPAC Name(1-hydroxy-1-phosphonoethyl)phosphonic acid
InChIInChI=1S/C2H8O7P2/c1-2(3,10(4,5)6)11(7,8)9/h3H,1H3,(H2,4,5,6)(H2,7,8,9)
InChIKeyDBVJJBKOTRCVKF-UHFFFAOYSA-N
SMILESCC(O)(P(=O)(O)O)P(=O)(O)O