Ethacrynic acid

• CAT Number: R048634
• CAS Number: 58-54-8
• Molecular Formula: C13H12Cl2O4
• Molecular Weight: 303.14
• Purity: ≥95%
• Synonyms: 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid
• InChI: InChI=1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
• InChIKey: AVOLMBLBETYQHX-UHFFFAOYSA-N
• SMILES: CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl

Ethacrynic acid（Cat No.:R048634）is a loop diuretic belonging to the phenoxyacetic acid class, distinct from sulfonamide-based diuretics. It inhibits the Na⁺/K⁺/2Cl⁻ cotransporter in the thick ascending limb of Henle’s loop, leading to increased excretion of sodium, chloride, potassium, and water. Clinically, it has been used to manage edema associated with heart failure, liver cirrhosis, renal disease, and hypertension, particularly in patients allergic to sulfonamides. Ethacrynic acid also exhibits alkylating properties, allowing study of glutathione-dependent detoxification pathways. It remains a valuable tool in renal physiology and pharmacology research.