Et-29

• CAT Number: I045079
• CAS Number: 2166487-23-4
• Molecular Formula: C34H46N6O6S
• Molecular Weight: 666.83
• Purity: ≥95%
• Synonyms: ethyl 3-[[(5S)-6-[[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(propan-2-ylamino)propan-2-yl]amino]-6-oxo-5-(phenylmethoxycarbonylamino)hexyl]carbamothioylamino]propanoate
• InChI: InChI=1S/C34H46N6O6S/c1-4-45-30(41)17-19-36-33(47)35-18-11-10-16-28(40-34(44)46-22-24-12-6-5-7-13-24)31(42)39-29(32(43)38-23(2)3)20-25-21-37-27-15-9-8-14-26(25)27/h5-9,12-15,21,23,28-29,37H,4,10-11,16-20,22H2,1-3H3,(H,38,43)(H,39,42)(H,40,44)(H2,35,36,47)/t28-,29-/m0/s1
• InChIKey: DCENHWUVADDCEN-VMPREFPWSA-N
• SMILES: CCOC(=O)CCNC(=S)NCCCC[C@@H](C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)NC(C)C)NC(=O)OCC3=CC=CC=C3

ET-29（Cat No.:I045079）is a potent and selective inhibitor of NADPH oxidase 2 (NOX2), an enzyme complex involved in the generation of reactive oxygen species (ROS). By targeting NOX2, ET-29 reduces oxidative stress and inflammation, processes implicated in various pathological conditions including neurodegenerative diseases, cardiovascular disorders, and chronic inflammation. Preclinical studies suggest ET-29 effectively modulates ROS production without broadly suppressing immune function, making it a promising candidate for diseases driven by NOX2 overactivation. Its selectivity and favorable pharmacological profile support further investigation as a therapeutic agent targeting oxidative damage.