Estetrol - CAS 15183-37-6

Estetrol is is a potent, orally bioavailable, natural human fetal selective estrogen receptor modulator, since it acts in the rat as an estrogen on all tissues investigated except breast tumor tissue, where it has estrogen antagonistic properties in the presence of estradiol. Estetrol attenuates neonatal hypoxic-ischemic brain injury. Estetrol may be suitable as a potential drug for human use in applications such as hormone replacement therapy (vaginal atrophy, hot flushes), contraception and osteoporosis. Additional areas worth exploring are the treatment of breast and prostate cancer, hypoactive sexual desire disorder and topical use.

Catalog Number: R010032

CAS Number: 15183-37-6

PubChem Substance ID:355164417

Molecular Formula: C18H24O4

Molecular Weight:304.386

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms(15α,16α,17β)-Estra-1,3,5(10)-triene-3,15,16,17-tetrol; ?Estra-1,3,5(10)-triene-3,15α,16α,17β-tetrol; 15α-Hydroxyestriol; 3,15α,16α,17β-Tetrahydroxyestra-1,3,5(10)-triene;

Property

Molecular Formula: C18H24O4
Molecular Weight304.386
Purity≥95%
Storage-20°C

Computed Descriptor

IUPAC Name(8R,9S,13S,14S,15R,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,15,16,17-tetrol
InChIInChI=1S/C18H24O4/c1-18-7-6-12-11-5-3-10(19)8-9(11)2-4-13(12)14(18)15(20)16(21)17(18)22/h3,5,8,12-17,19-22H,2,4,6-7H2,1H3/t12-,13-,14-,15-,16-,17+,18+/m1/s1
InChIKeyAJIPIJNNOJSSQC-NYLIRDPKSA-N
SMILESCC12CCC3C(C1C(C(C2O)O)O)CCC4=C3C=CC(=C4)O