For research use only. Not for therapeutic Use.
ESI-05（Cat No.:I012653）is a selective small-molecule inhibitor of exchange protein directly activated by cAMP 2 (Epac2), a guanine nucleotide exchange factor involved in cAMP-mediated signaling. By specifically blocking Epac2, ESI-05 enables researchers to distinguish Epac2-driven pathways from Epac1 and protein kinase A (PKA) signaling. It has been used in studies of insulin secretion, pancreatic β-cell function, cardiovascular regulation, and neuronal signaling. With its high selectivity, ESI-05 serves as a powerful pharmacological tool for exploring cAMP-dependent processes and developing therapeutic strategies in diabetes, metabolic, and neurological research.
| CAS Number | 5184-64-5 |
| Synonyms | 1,3,5-trimethyl-2-(4-methylphenyl)sulfonylbenzene |
| Molecular Formula | C16H18O2S |
| Purity | ≥95% |
| IUPAC Name | 1,3,5-trimethyl-2-(4-methylphenyl)sulfonylbenzene |
| InChI | InChI=1S/C16H18O2S/c1-11-5-7-15(8-6-11)19(17,18)16-13(3)9-12(2)10-14(16)4/h5-10H,1-4H3 |
| InChIKey | CGPHOZWFSFNOEQ-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)C2=C(C=C(C=C2C)C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
