ErSO

• CAT Number: I026990
• CAS Number: 2407860-35-7
• Molecular Formula: C22H13F6NO3
• Molecular Weight: 453.33
• Purity: ≥95%

ErSO (Cat No.: I026990) is a small-molecule therapeutic designed to selectively activate the anticipatory unfolded protein response (a-UPR) in estrogen receptor-positive (ER+) cancer cells. By triggering sustained endoplasmic reticulum stress through estrogen receptor engagement, ErSO induces rapid and selective tumor cell death while sparing normal tissues. It demonstrates potent antitumor activity in preclinical models, including those resistant to conventional endocrine therapies. ErSO represents a novel approach to targeting ER+ cancers by exploiting a unique stress response pathway, with potential for durable and selective cancer treatment.

Reference

[1]. Boudreau MW, et al. A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice. Sci Transl Med. 2021;13(603):eabf1383.
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