Eribulin-d3 mesylate

• CAT Number: I045299
• Molecular Formula: C41H60D3NO14S
• Molecular Weight: 829.02
• Purity: ≥95%
• Synonyms: (1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-14-methyl-8,15-dimethylidene-21-(trideuteriomethoxy)-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.13,32.13,33.16,9.112,16.018,22.029,36.031,35]hentetracontan-24-one;methanesulfonic acid
• InChI: InChI=1S/C40H59NO11.CH4O3S/c1-19-11-24-5-7-28-20(2)12-26(45-28)9-10-40-17-33-36(51-40)37-38(50-33)39(52-40)35-29(49-37)8-6-25(47-35)13-22(42)14-27-31(16-30(46-24)21(19)3)48-32(34(27)44-4)15-23(43)18-41;1-5(2,3)4/h19,23-39,43H,2-3,5-18,41H2,1,4H3;1H3,(H,2,3,4)/t19-,23+,24+,25-,26+,27+,28+,29+,30-,31+,32-,33-,34-,35+,36+,37+,38-,39+,40+;/m1./s1/i4D3
• InChIKey: QAMYWGZHLCQOOJ-OGUHGQNFSA-N
• SMILES: [2H]C([2H])([2H])O[C@@H]1[C@H]2CC(=O)C[C@H]3CC[C@H]4[C@H](O3)[C@H]5[C@H]6[C@@H](O4)[C@@H]7[C@H](O6)C[C@@](O7)(O5)CC[C@H]8CC(=C)[C@@H](O8)CC[C@H]9C[C@H](C(=C)[C@H](O9)C[C@@H]2O[C@@H]1C[C@@H](CN)O)C.CS(=O)(=O)O

Eribulin-d3 mesylate（Cat No.:I045299）is a deuterium-labeled analog of eribulin mesylate, a synthetic microtubule dynamics inhibitor derived from halichondrin B. The incorporation of three deuterium atoms enables its use as an internal standard in quantitative LC–MS/MS bioanalytical assays, improving accuracy and reproducibility in pharmacokinetic and metabolic studies. Like the parent drug, it targets tubulin to inhibit microtubule growth, disrupting mitotic spindle formation and inducing apoptosis in cancer cells. Eribulin-d3 mesylate is primarily applied in research supporting drug development, therapeutic monitoring, and the study of eribulin’s distribution, metabolism, and clearance in biological systems.