Erdafitinib - CAS 1346242-81-6
Erdafitinib,(CAT: I001324) is a potent and selective inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinases. By targeting FGFRs, erdafitinib interferes with aberrant signaling pathways involved in cell growth, survival, and angiogenesis. This pharmacologic action makes erdafitinib particularly effective against cancers harboring specific FGFR genetic alterations, such as FGFR2 fusions or mutations. Erdafitinib has demonstrated clinical efficacy in the treatment of metastatic urothelial carcinoma, providing a targeted therapeutic option for patients with these genetic alterations.
Catalog Number: I001324
CAS Number: 1346242-81-6
PubChem Substance ID:355038003
Molecular Formula: C25H30N6O2
Molecular Weight:446.5
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
| Synonyms | Erdafitinib |
|---|
Property
| Molecular Formula: | C25H30N6O2 |
|---|---|
| Molecular Weight | 446.5 |
| Target: | FGFR |
| Solubility | DMSO: ≥ 33 mg/mL |
| Purity | ≥95% |
| Storage | -20°C |
| IC50 | 9/8.5/8.5/8.25 (pIC50, for FGFR1/2/3/4) |
Computed Descriptor
| IUPAC Name | N'-(3,5-dimethoxyphenyl)-N'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-N-propan-2-ylethane-1,2-diamine |
|---|---|
| InChI | InChI=1S/C25H30N6O2/c1-17(2)26-8-9-31(20-10-21(32-4)13-22(11-20)33-5)19-6-7-23-24(12-19)29-25(15-27-23)18-14-28-30(3)16-18/h6-7,10-17,26H,8-9H2,1-5H3 |
| InChIKey | OLAHOMJCDNXHFI-UHFFFAOYSA-N |
| SMILES | COC1=CC(OC)=CC(N(CCNC(C)C)C2=CC=C(N=CC(C3=CN(C)N=C3)=N4)C4=C2)=C1 |