EPZ020411 hydrochloride - CAS 2070015-25-5

EPZ020411 hydrochloride is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has >10 fold selectivity for PRMT6 over PRMT1 and PRMT8.
in vitro: EPZ020411 inhibits methylation of PRMT6 substrates in cells. EPZ020411 does-dependently inhibits H3R2 methylation in PRMT6-overexpressing cells.
in vivo: EPZ020411 shows good bioavailability following subcutaneous (SC) dosing in rats making it a suitable tool for in vivo studies.

Catalog Number: I005793

CAS Number: 2070015-25-5

PubChem Substance ID:355049011

Molecular Formula: C25H39ClN4O3

Molecular Weight:479.06

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

SynonymsEPZ020411

Property

Molecular Formula: C25H39ClN4O3
Molecular Weight479.06
Target:PRMT6
SolubilityH2O: ≥ 41 mg/mL
Purity≥95%
StorageStore at -20°C
IC5010 nM