Eplivanserin hemifumarate

• CAT Number: I006688
• CAS Number: 130580-02-8
• Molecular Formula: C19H21FN2O2.1/2C4H4O4
• Molecular Weight: 386.43
• Purity: ≥95%

Eplivanserin hemifumarate (Cat No.: I006688) is a selective antagonist of the serotonin 5-HT2A receptor, investigated for its potential role in treating sleep disorders such as insomnia. By blocking 5-HT2A receptor activity, it promotes slow-wave sleep without significantly affecting rapid eye movement (REM) sleep, offering a unique mechanism compared to traditional hypnotics. Researchers have explored its effects on sleep architecture, mood regulation, and circadian rhythm. Although clinical development was discontinued, eplivanserin hemifumarate remains a useful compound in neuropharmacology and sleep research studies.

Reference

[1]. Rinaldi-Carmona M, et al. Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist. J Pharmacol Exp Ther. 1992 Aug;262(2):759-68.
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[2]. Malgorzata Filip, et al. Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses. J Pharmacol Exp Ther. 2004 Sep;310(3):1246-54.
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