Epitalon

• CAT Number: P000345
• CAS Number: 307297-39-8
• Molecular Formula: C14H22N4O9
• Molecular Weight: 390.35
• Purity: ≥95%
• Synonyms: (4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
• InChI: InChI=1S/C14H22N4O9/c1-6(15)12(25)17-7(2-3-9(19)20)14(27)18-8(4-10(21)22)13(26)16-5-11(23)24/h6-8H,2-5,15H2,1H3,(H,16,26)(H,17,25)(H,18,27)(H,19,20)(H,21,22)(H,23,24)/t6-,7-,8-/m0/s1
• InChIKey: HGHOBRRUMWJWCU-FXQIFTODSA-N
• SMILES: C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)O)N

Epitalon (Cat No.:P000345) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from a natural pineal gland extract. It is known for its potential anti-aging and telomerase-activating properties, which may support cellular longevity and genomic stability. Epitalon has been studied for its ability to regulate melatonin secretion, improve circadian rhythm, and enhance resistance to oxidative stress. It is primarily used in experimental gerontology and regenerative medicine research. Typically administered via injection, Epitalon is stable, water-soluble, and has shown promise in extending lifespan in preclinical animal studies.

Reference

[1]. Khavinson VKh. et al. Peptides and Ageing. Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144.
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[2]. Vanhee C, et al. Identification of the small research tetra peptide Epitalon, assumed to be a potential treatment for cancer, old age and Retinitis Pigmentosa in two illegal pharmaceutical preparations. Drug Test Anal. 2015 Mar;7(3):259-64.
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[3]. Khavinson VKh, et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2.
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