For research use only. Not for therapeutic Use.
Epertinib hydrochloride(Cat No.:I017995)is an orally bioavailable small-molecule tyrosine kinase inhibitor that selectively targets members of the epidermal growth factor receptor (EGFR/HER) family, including EGFR, HER2, and HER4. By blocking receptor phosphorylation and downstream signaling, it suppresses cellular proliferation, survival, and migration. Epertinib has been investigated for its potential in treating HER2-positive breast cancer and EGFR-driven tumors, particularly in cases resistant to first-line therapies. The hydrochloride salt improves solubility and experimental use.
CAS Number | 2071195-74-7 |
Synonyms | N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[(Z)-N-[[(3R)-morpholin-3-yl]methoxy]-C-prop-1-ynylcarbonimidoyl]quinazolin-4-amine;hydrochloride |
Molecular Formula | C30H28Cl2FN5O3 |
Purity | ≥95% |
IUPAC Name | N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[(Z)-N-[[(3R)-morpholin-3-yl]methoxy]-C-prop-1-ynylcarbonimidoyl]quinazolin-4-amine;hydrochloride |
InChI | InChI=1S/C30H27ClFN5O3.ClH/c1-2-4-27(37-40-18-24-17-38-12-11-33-24)21-7-9-28-25(14-21)30(35-19-34-28)36-23-8-10-29(26(31)15-23)39-16-20-5-3-6-22(32)13-20;/h3,5-10,13-15,19,24,33H,11-12,16-18H2,1H3,(H,34,35,36);1H/b37-27+;/t24-;/m1./s1 |
InChIKey | NVWJPQQXBPWOOA-PLXRJBJVSA-N |
SMILES | CC#C/C(=N\OC[C@H]1COCCN1)/C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.Cl |
Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |