Enzalutamide carboxylic acid-d6

• CAT Number: I046018
• Molecular Formula: C20H7D6F4N3O3S
• Molecular Weight: 457.43
• Purity: ≥95%
• Synonyms: 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-4-oxo-2-sulfanylidene-5,5-bis(trideuteriomethyl)imidazolidin-1-yl]-2-fluorobenzoic acid
• InChI: InChI=1S/C20H13F4N3O3S/c1-19(2)17(30)26(11-4-3-10(9-25)14(7-11)20(22,23)24)18(31)27(19)12-5-6-13(16(28)29)15(21)8-12/h3-8H,1-2H3,(H,28,29)/i1D3,2D3
• InChIKey: MECDPCCFIDQBBP-WFGJKAKNSA-N
• SMILES: CC1(C(=O)N(C(=S)N1C2=CC(=C(C=C2)C(=O)O)F)C3=CC(=C(C=C3)C#N)C(F)(F)F)C

Enzalutamide carboxylic acid-d6(CAT: I046018) is a stable isotope-labeled analog of Enzalutamide carboxylic acid, the major metabolite of the androgen receptor (AR) antagonist Enzalutamide. In this compound, six deuterium atoms replace hydrogen atoms, providing an ideal internal standard for LC-MS/MS quantification in pharmacokinetic, metabolism, and bioanalytical studies. Enzalutamide carboxylic acid-d6 retains the same chemical structure and metabolic profile as the unlabeled metabolite, ensuring accurate measurement of drug exposure, clearance, and metabolite identification. It is widely used in oncology research, particularly in studies investigating androgen receptor signaling and the pharmacological assessment of prostate cancer therapeutics.