For research use only. Not for therapeutic Use.
Ensitrelvir fumarate（Cat No.:I045199）is an orally active inhibitor of the SARS-CoV-2 main protease (Mpro, 3CLpro), essential for viral polyprotein processing and replication. By blocking Mpro activity, it halts viral replication at an early stage of the infection cycle. Developed as a COVID-19 therapeutic, Ensitrelvir fumarate has shown potent antiviral activity against multiple SARS-CoV-2 variants, including Omicron, in preclinical and clinical studies. Its favorable oral bioavailability enables convenient outpatient treatment. Ensitrelvir fumarate is a valuable tool in antiviral research and holds promise for pandemic preparedness and coronavirus-targeted drug development.
| CAS Number | 2757470-18-9 |
| Synonyms | (E)-but-2-enedioic acid;6-[(6-chloro-2-methylindazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[(2,4,5-trifluorophenyl)methyl]-1,3,5-triazine-2,4-dione |
| Molecular Formula | C26H21ClF3N9O6 |
| Purity | ≥95% |
| IUPAC Name | (E)-but-2-enedioic acid;6-[(6-chloro-2-methylindazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[(2,4,5-trifluorophenyl)methyl]-1,3,5-triazine-2,4-dione |
| InChI | InChI=1S/C22H17ClF3N9O2.C4H4O4/c1-32-7-12-4-18(13(23)5-17(12)30-32)28-20-29-21(36)35(9-19-27-10-33(2)31-19)22(37)34(20)8-11-3-15(25)16(26)6-14(11)24;5-3(6)1-2-4(7)8/h3-7,10H,8-9H2,1-2H3,(H,28,29,36);1-2H,(H,5,6)(H,7,8)/b;2-1+ |
| InChIKey | FBOCUALVLIWPNQ-WLHGVMLRSA-N |
| SMILES | CN1C=C2C=C(C(=CC2=N1)Cl)NC3=NC(=O)N(C(=O)N3CC4=CC(=C(C=C4F)F)F)CC5=NN(C=N5)C.C(=C/C(=O)O)\C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
