Enpp/Carbonic anhydrase-IN-2

• CAT Number: I042386
• CAS Number: 2883495-39-2
• Molecular Formula: C23H24FNO4S
• Molecular Weight: 429.50
• Purity: ≥95%
• Synonyms: [4-(adamantane-1-carbonylamino)phenyl] 4-fluorobenzenesulfonate
• InChI: InChI=1S/C23H24FNO4S/c24-18-1-7-21(8-2-18)30(27,28)29-20-5-3-19(4-6-20)25-22(26)23-12-15-9-16(13-23)11-17(10-15)14-23/h1-8,15-17H,9-14H2,(H,25,26)
• InChIKey: LLXLLGJJXOHBLG-UHFFFAOYSA-N
• SMILES: C1C2CC3CC1CC(C2)(C3)C(=O)NC4=CC=C(C=C4)OS(=O)(=O)C5=CC=C(C=C5)F

Enpp/Carbonic anhydrase-IN-2 (Cat No.: I042386) is a dual inhibitor designed to target both ectonucleotide pyrophosphatase/phosphodiesterase (ENPP) enzymes and carbonic anhydrases. ENPPs regulate extracellular nucleotide levels, affecting immune responses and tumor microenvironment, while carbonic anhydrases control pH balance and are often upregulated in cancer. By simultaneously inhibiting both enzyme classes, Enpp/Carbonic anhydrase-IN-2 disrupts metabolic and signaling pathways essential for tumor survival and immune evasion. This compound is valuable in cancer and inflammation research, supporting the development of multi-targeted therapeutic strategies.

Reference

[1]. Afnan I.Shahin, et al. Design and synthesis of new adamantyl derivatives as promising antiproliferative agents. European Journal of Medicinal Chemistry, 2022.