Enpp/Carbonic anhydrase-IN-1

• CAT Number: I042387
• CAS Number: 2883495-35-8
• Molecular Formula: C23H25NO4S
• Molecular Weight: 411.51
• Purity: ≥95%
• Synonyms: [4-(adamantane-1-carbonylamino)phenyl] benzenesulfonate
• InChI: InChI=1S/C23H25NO4S/c25-22(23-13-16-10-17(14-23)12-18(11-16)15-23)24-19-6-8-20(9-7-19)28-29(26,27)21-4-2-1-3-5-21/h1-9,16-18H,10-15H2,(H,24,25)
• InChIKey: NYTJZFKTUQYXEN-UHFFFAOYSA-N
• SMILES: C1C2CC3CC1CC(C2)(C3)C(=O)NC4=CC=C(C=C4)OS(=O)(=O)C5=CC=CC=C5

Enpp/Carbonic anhydrase-IN-1 (Cat No.: I042387) is a dual inhibitor targeting ectonucleotide pyrophosphatase/phosphodiesterase (ENPP) and carbonic anhydrase enzymes, both of which play critical roles in extracellular nucleotide metabolism and pH regulation, respectively. By inhibiting ENPP, this compound reduces nucleotide hydrolysis, affecting immune signaling and tumor microenvironment dynamics. Simultaneous inhibition of carbonic anhydrase disrupts pH balance, impairing cancer cell survival and proliferation. Enpp/Carbonic anhydrase-IN-1 is primarily used in oncology and immunometabolism research to explore novel therapeutic strategies against tumors and inflammatory diseases.

Reference

[1]. Afnan I.Shahin, et al. Design and synthesis of new adamantyl derivatives as promising antiproliferative agents. European Journal of Medicinal Chemistry, 2022.