For research use only. Not for therapeutic Use.
ENPP-1-IN-5（Cat No.:I044162）is a selective small-molecule inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), an enzyme that hydrolyzes extracellular cyclic GMP-AMP (cGAMP), a key activator of the STING (Stimulator of Interferon Genes) pathway. By inhibiting ENPP1, ENPP-1-IN-5 enhances cGAMP stability and amplifies innate immune responses, making it a promising candidate for cancer immunotherapy. It is used in preclinical research to study the modulation of antitumor immunity, particularly in combination with immune checkpoint inhibitors. ENPP-1-IN-5 also aids in investigating ENPP1’s role in bone mineralization, insulin resistance, and cardiovascular disease.
| CAS Number | 2230916-95-5 |
| Synonyms | 2-amino-6,7-dimethoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline |
| Molecular Formula | C17H26N6O4S |
| Purity | ≥95% |
| IUPAC Name | 2-amino-6,7-dimethoxy-4-[4-[2-(sulfamoylamino)ethyl]piperidin-1-yl]quinazoline |
| InChI | InChI=1S/C17H26N6O4S/c1-26-14-9-12-13(10-15(14)27-2)21-17(18)22-16(12)23-7-4-11(5-8-23)3-6-20-28(19,24)25/h9-11,20H,3-8H2,1-2H3,(H2,18,21,22)(H2,19,24,25) |
| InChIKey | HXYGEHWQWCYBGY-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C2C(=C1)C(=NC(=N2)N)N3CCC(CC3)CCNS(=O)(=O)N)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
