Enpp-1-IN-1

• CAT Number: I017793
• CAS Number: 2289728-58-9
• Molecular Formula: C17H17N3O3S
• Molecular Weight: 343.40
• Purity: ≥95%
• Synonyms: 7-methoxy-4-[4-[(sulfamoylamino)methyl]phenyl]quinoline
• InChI: InChI=1S/C17H17N3O3S/c1-23-14-6-7-16-15(8-9-19-17(16)10-14)13-4-2-12(3-5-13)11-20-24(18,21)22/h2-10,20H,11H2,1H3,(H2,18,21,22)
• InChIKey: UEJMNZDIQDULLP-UHFFFAOYSA-N
• SMILES: COC1=CC2=NC=CC(=C2C=C1)C3=CC=C(C=C3)CNS(=O)(=O)N

ENPP-1-IN-1（Cat No.:I017793）is a selective small-molecule inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), an enzyme that hydrolyzes extracellular nucleotides such as cGAMP. By blocking ENPP1 activity, this compound preserves cGAMP-mediated STING signaling, enhancing innate immune activation and antitumor responses. ENPP-1-IN-1 is a valuable research tool for studying tumor immunology, inflammatory regulation, and nucleotide metabolism. Its selective inhibition supports exploration of novel immunotherapeutic strategies, particularly in cancer and infectious disease models. ENPP-1-IN-1 highlights the potential of targeting extracellular nucleotide pathways to boost host defense mechanisms.