For research use only. Not for therapeutic Use.
Enpatoran (Cat No.:I026885) is an orally active, selective dual inhibitor of Toll-like receptors 7 and 8 (TLR7/8), which are key components of the innate immune system involved in recognizing single-stranded RNA and triggering pro-inflammatory cytokine production. By blocking TLR7/8 signaling, enpatoran reduces the release of cytokines like interferon-α and TNF-α, making it a promising candidate for treating autoimmune and inflammatory diseases such as systemic lupus erythematosus and psoriasis. It is also being explored for hyperinflammatory conditions, including COVID-19. Enpatoran offers targeted immunomodulation with a favorable safety and pharmacokinetic profile.
| CAS Number | 2101938-42-3 |
| Synonyms | 5-[(3R,5S)-3-amino-5-(trifluoromethyl)piperidin-1-yl]quinoline-8-carbonitrile |
| Molecular Formula | C16H15F3N4 |
| Purity | ≥95% |
| IUPAC Name | 5-[(3R,5S)-3-amino-5-(trifluoromethyl)piperidin-1-yl]quinoline-8-carbonitrile |
| InChI | InChI=1S/C16H15F3N4/c17-16(18,19)11-6-12(21)9-23(8-11)14-4-3-10(7-20)15-13(14)2-1-5-22-15/h1-5,11-12H,6,8-9,21H2/t11-,12+/m0/s1 |
| InChIKey | BJXYHBKEQFQVES-NWDGAFQWSA-N |
| SMILES | C1[C@@H](CN(C[C@@H]1N)C2=C3C=CC=NC3=C(C=C2)C#N)C(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
