For research use only. Not for therapeutic Use.
Enpatoran hydrochloride（Cat No.:I044566）is the hydrochloride salt form of enpatoran (also known as M5049), a potent and selective dual inhibitor of Toll-like receptors 7 and 8 (TLR7/8). These receptors play crucial roles in innate immune activation and are implicated in autoimmune and inflammatory diseases. By blocking TLR7/8 signaling, enpatoran hydrochloride reduces the production of pro-inflammatory cytokines such as type I interferons and TNF-α. It is being investigated for conditions like systemic lupus erythematosus and COVID-19–related hyperinflammation. Enpatoran hydrochloride offers a targeted approach to modulating innate immune responses with favorable pharmacokinetics.
| CAS Number | 2101945-93-9 |
| Synonyms | 5-[(3R,5S)-3-amino-5-(trifluoromethyl)piperidin-1-yl]quinoline-8-carbonitrile;hydrochloride |
| Molecular Formula | C16H16ClF3N4 |
| Purity | ≥95% |
| IUPAC Name | 5-[(3R,5S)-3-amino-5-(trifluoromethyl)piperidin-1-yl]quinoline-8-carbonitrile;hydrochloride |
| InChI | InChI=1S/C16H15F3N4.ClH/c17-16(18,19)11-6-12(21)9-23(8-11)14-4-3-10(7-20)15-13(14)2-1-5-22-15;/h1-5,11-12H,6,8-9,21H2;1H/t11-,12+;/m0./s1 |
| InChIKey | OHYZGHQWGHDMRP-ZVWHLABXSA-N |
| SMILES | C1[C@@H](CN(C[C@@H]1N)C2=C3C=CC=NC3=C(C=C2)C#N)C(F)(F)F.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
