Enfumafungin

• CAT Number: I044808
• CAS Number: 260979-95-1
• Molecular Formula: C38H60O12
• Molecular Weight: 708.88
• Purity: ≥95%
• Synonyms: (1R,5S,6R,7R,10R,11R,14S,15S,20R,21R)-20-acetyloxy-18-hydroxy-5,7,10,15-tetramethyl-7-[(2R)-3-methylbutan-2-yl]-21-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-17-oxapentacyclo[13.3.3.01,14.02,11.05,10]henicos-2-ene-6-carboxylic acid
• InChI: InChI=1S/C38H60O12/c1-18(2)19(3)34(5)13-14-36(7)21-9-10-25-35(6)17-47-33(46)38(25,22(21)11-12-37(36,8)29(34)31(44)45)15-23(48-20(4)40)30(35)50-32-28(43)27(42)26(41)24(16-39)49-32/h11,18-19,21,23-30,32-33,39,41-43,46H,9-10,12-17H2,1-8H3,(H,44,45)/t19-,21+,23-,24-,25+,26-,27+,28-,29-,30+,32+,33?,34-,35-,36-,37+,38+/m1/s1
• InChIKey: IAOFPTKYKOAKGZ-CRWQHXLTSA-N
• SMILES: C[C@H](C(C)C)[C@]1(CC[C@@]2([C@H]3CC[C@H]4[C@]5(COC([C@]4(C3=CC[C@]2([C@@H]1C(=O)O)C)C[C@H]([C@@H]5O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)OC(=O)C)O)C)C)C

Enfumafungin（Cat No.:I044808）is a triterpenoid glycoside antifungal compound derived from the fungus Hormonema species. It features a unique fusidane-type structure and exhibits potent activity against fungal pathogens by targeting β-1,3-glucan synthase, an essential enzyme for fungal cell wall synthesis. Unlike many traditional antifungals, enfumafungin offers a novel mechanism of action, making it effective against resistant strains of Candida and Aspergillus. Its promising pharmacological profile has led to the development of enfumafungin-derived drugs like ibrexafungerp. Enfumafungin represents a valuable lead compound for next-generation antifungal therapies with improved efficacy and resistance profiles.