endo-BCN-PEG3-mal

• CAT Number: I016262
• CAS Number: 2141976-33-0
• Molecular Formula: C26H37N3O8
• Molecular Weight: 519.59
• Purity: ≥95%
• Synonyms: [(1R,8S)-9-bicyclo[6.1.0]non-4-ynyl]methyl N-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethyl]carbamate
• IUPAC Name: [(1S,8R)-9-bicyclo[6.1.0]non-4-ynyl]methyl N-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethyl]carbamate
• InChI: InChI=1S/C26H37N3O8/c30-23(9-12-29-24(31)7-8-25(29)32)27-10-13-34-15-17-36-18-16-35-14-11-28-26(33)37-19-22-20-5-3-1-2-4-6-21(20)22/h7-8,20-22H,3-6,9-19H2,(H,27,30)(H,28,33)/t20-,21+,22?
• InChIKey: ZZRUYTQNTVMKLG-CBQGHPETSA-N
• SMILES: C1CC2C(C2COC(=O)NCCOCCOCCOCCNC(=O)CCN3C(=O)C=CC3=O)CCC#C1

endo-BCN-PEG3-Mal(CAT: I016262) is a heterobifunctional crosslinker featuring a strained bicyclo[6.1.0]nonyne (BCN) group and a maleimide moiety connected through a triethylene glycol (PEG3) spacer. The BCN group enables rapid, catalyst-free strain-promoted azide–alkyne cycloaddition (SPAAC), while the maleimide reacts selectively with thiols, allowing precise conjugation to cysteine residues in peptides, proteins, or antibodies. The PEG3 spacer enhances aqueous solubility, reduces steric hindrance, and improves biocompatibility. This dual-reactive linker is valuable for inhibitor design, targeted drug delivery, and site-specific bioconjugation, particularly in cancer, immunology, and metabolic disease research where stable and efficient covalent coupling is critical.