Encelimab

• CAT Number: I040367
• CAS Number: 2173096-82-5
• Purity: ≥95%

Encelimab(CAT: I040367) is a humanized monoclonal antibody designed to block V-domain Ig suppressor of T cell activation (VISTA), an immune checkpoint receptor involved in suppressing T cell responses and maintaining peripheral tolerance. By targeting VISTA, Encelimab aims to reinvigorate T cell activity and enhance antitumor immunity, particularly in cancers where VISTA is upregulated in the tumor microenvironment. It is being investigated as a potential immunotherapeutic agent for solid tumors and hematological malignancies, either alone or in combination with other checkpoint inhibitors. Encelimab represents a next-generation approach to immune modulation, offering new avenues for overcoming resistance to existing cancer immunotherapies.