For research use only. Not for therapeutic Use.
EN40(CAT: I017632) is a potent and selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor that functions as a covalent ligand, with an IC₅₀ of 2 μM. In vitro, EN40 (10–1000 μM, 48 h) significantly inhibits ALDH3A1 activity and reduces A549 lung cancer cell survival, highlighting its anticancer potential. In vivo, intraperitoneal administration of EN40 (50 mg/kg, daily for 14 days) strongly suppresses tumor growth in established A549 xenografts, demonstrating both efficacy and good tolerability without weight loss in treated mice. EN40 represents a valuable chemical probe and therapeutic candidate for studying ALDH3A1 biology and tumor metabolism in cancer research.
| CAS Number | 2094547-67-6 |
| Synonyms | 1-[5-(furan-2-yl)-4-methyl-3,6-dihydro-2H-pyridin-1-yl]prop-2-en-1-one |
| Molecular Formula | C13H15NO2 |
| Purity | ≥95% |
| IUPAC Name | 1-[5-(furan-2-yl)-4-methyl-3,6-dihydro-2H-pyridin-1-yl]prop-2-en-1-one |
| InChI | InChI=1S/C13H15NO2/c1-3-13(15)14-7-6-10(2)11(9-14)12-5-4-8-16-12/h3-5,8H,1,6-7,9H2,2H3 |
| InChIKey | UYNKILJNUUDFFJ-UHFFFAOYSA-N |
| SMILES | CC1=C(CN(CC1)C(=O)C=C)C2=CC=CO2 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
