For research use only. Not for therapeutic Use.
EN219 (Cat No.: I026833) is a covalent small-molecule E3 ligase recruiter used in the development of proteolysis-targeting chimeras (PROTACs) and targeted protein degradation strategies. By binding covalently to specific cysteine residues on an E3 ubiquitin ligase, EN219 enables the design of bifunctional molecules that direct disease-relevant proteins to the ubiquitin–proteasome system for degradation. It has been applied in chemical biology, oncology, and drug discovery research. EN219 provides a valuable tool for exploring E3 ligase biology, ubiquitination pathways, and therapeutic development.
| CAS Number | 380351-29-1 |
| Synonyms | 1-[3,5-bis(4-bromophenyl)-3,4-dihydropyrazol-2-yl]-2-chloroethanone |
| Molecular Formula | C17H13Br2ClN2O |
| Purity | ≥95% |
| InChI | InChI=1S/C17H13Br2ClN2O/c18-13-5-1-11(2-6-13)15-9-16(22(21-15)17(23)10-20)12-3-7-14(19)8-4-12/h1-8,16H,9-10H2 |
| InChIKey | CXRHMHAKZPJNKS-UHFFFAOYSA-N |
| SMILES | C1C(N(N=C1C2=CC=C(C=C2)Br)C(=O)CCl)C3=CC=C(C=C3)Br |
| Reference | [1]. Luo M, et al. Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28(4):559-566.e15. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
