For research use only. Not for therapeutic Use.
Emraclidine (Cat No.: I026831) is a novel, investigational positive allosteric modulator (PAM) of the M4 muscarinic acetylcholine receptor, developed for the treatment of schizophrenia and other neuropsychiatric disorders. By selectively enhancing M4 receptor activity, emraclidine modulates dopaminergic signaling in key brain regions without directly targeting dopamine receptors, potentially reducing psychotic symptoms with fewer side effects than traditional antipsychotics. It offers a promising non-dopaminergic approach to managing schizophrenia and is currently being evaluated in clinical trials for efficacy and safety in long-term use.
| CAS Number | 2170722-84-4 |
| Synonyms | 1-(2,4-dimethyl-5,7-dihydropyrrolo[3,4-b]pyridin-6-yl)-2-[1-[2-(trifluoromethyl)pyridin-4-yl]azetidin-3-yl]ethanone |
| Molecular Formula | C20H21F3N4O |
| Purity | ≥95% |
| InChI | InChI=1S/C20H21F3N4O/c1-12-5-13(2)25-17-11-27(10-16(12)17)19(28)6-14-8-26(9-14)15-3-4-24-18(7-15)20(21,22)23/h3-5,7,14H,6,8-11H2,1-2H3 |
| InChIKey | DTCZNKWBDTXEBS-UHFFFAOYSA-N |
| SMILES | CC1=CC(=NC2=C1CN(C2)C(=O)CC3CN(C3)C4=CC(=NC=C4)C(F)(F)F)C |
| Reference | [1]. WO2018002760 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
