For research use only. Not for therapeutic Use.
Emprumapimod（Cat No.:I045112）is an investigational oral small-molecule inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), a key regulator of pro-inflammatory cytokine production. It is being developed for the treatment of chronic inflammatory and neurodegenerative diseases, including acute exacerbations of chronic obstructive pulmonary disease (COPD) and heart failure. By inhibiting p38 MAPK, Emprumapimod reduces inflammation, oxidative stress, and tissue damage. Its targeted mechanism offers a potential therapeutic advantage with improved tolerability over broad-spectrum anti-inflammatories. Supplied for research into MAPK signaling, inflammation control, and related therapeutic innovations.
| CAS Number | 765914-60-1 |
| Synonyms | N-[(2S)-1-amino-4-(dimethylamino)-1-oxobutan-2-yl]-5-(2,4-difluorophenoxy)-1-(2-methylpropyl)indazole-6-carboxamide |
| Molecular Formula | C24H29F2N5O3 |
| Purity | ≥95% |
| IUPAC Name | N-[(2S)-1-amino-4-(dimethylamino)-1-oxobutan-2-yl]-5-(2,4-difluorophenoxy)-1-(2-methylpropyl)indazole-6-carboxamide |
| InChI | InChI=1S/C24H29F2N5O3/c1-14(2)13-31-20-11-17(24(33)29-19(23(27)32)7-8-30(3)4)22(9-15(20)12-28-31)34-21-6-5-16(25)10-18(21)26/h5-6,9-12,14,19H,7-8,13H2,1-4H3,(H2,27,32)(H,29,33)/t19-/m0/s1 |
| InChIKey | JOOOJNJPZINWHM-IBGZPJMESA-N |
| SMILES | CC(C)CN1C2=CC(=C(C=C2C=N1)OC3=C(C=C(C=C3)F)F)C(=O)N[C@@H](CCN(C)C)C(=O)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
