Empagliflozin α-Anomer

• CAT Number: R033639
• CAS Number: 1620758-33-9
• Molecular Formula: C23H27ClO7
• Molecular Weight: 450.91
• Purity: ≥95%
• Synonyms: (2R,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-, (1R)-
• Storage: -20°C
• IUPAC Name: (2R,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
• InChI: InChI=1S/C23H27ClO7/c24-18-6-3-14(23-22(28)21(27)20(26)19(11-25)31-23)10-15(18)9-13-1-4-16(5-2-13)30-17-7-8-29-12-17/h1-6,10,17,19-23,25-28H,7-9,11-12H2/t17-,19+,20+,21-,22+,23+/m0/s1
• InChIKey: OBWASQILIWPZMG-DNNBANOASA-N
• SMILES: C1COC[C@H]1OC2=CC=C(C=C2)CC3=C(C=CC(=C3)[C@@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)Cl

Empagliflozin α-anomer（Cat No.:R033639）is a stereoisomer of empagliflozin, a selective SGLT2 (sodium-glucose co-transporter 2) inhibitor used in type 2 diabetes management. While the β-anomer is the pharmacologically active form in approved drugs, the α-anomer differs in the stereochemistry of the glycosidic bond, affecting its biological activity and binding affinity. Structurally, it retains the C-glucoside linkage to a substituted phenyl ring with a key thioaryl moiety. The α-anomer is important in synthetic studies, analytical profiling, and understanding structure-activity relationships during drug development, quality control, and stereochemical analysis in pharmaceutical chemistry.