Emedastine Difumerate

For research use only. Not for therapeutic Use.

  • CAT Number: R043027
  • CAS Number: 87233-62-3
  • Molecular Formula: C25H34N4O9
  • Molecular Weight: 534.566
  • Purity: ≥95%
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Emedastine Difumarate is the difumarate salt form of emedastine, a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. This medication is an antihistamine, prescribed for allergic conjunctivitis. It blocks histamine/’s action, which reduces allergy symptoms. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its downstream activity. As a result, this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva.


Catalog Number R043027
CAS Number 87233-62-3
Synonyms

1H-1,4-Diazepine 1H-Benzimidazole deriv. Difumerate; 1-Methyl-4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane Difumerate;

Molecular Formula C25H34N4O9
Purity ≥95%
Target Histamine H1 Receptor Antagonist
Storage -20°C
IUPAC Name (E)-but-2-enedioic acid;1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole
InChI InChI=1S/C17H26N4O.2C4H4O4/c1-3-22-14-13-21-16-8-5-4-7-15(16)18-17(21)20-10-6-9-19(2)11-12-20;2*5-3(6)1-2-4(7)8/h4-5,7-8H,3,6,9-14H2,1-2H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1+
InChIKey FWLKKPKZQYVAFR-LVEZLNDCSA-N
SMILES CCOCCN1C2=CC=CC=C2N=C1N3CCCN(CC3)C.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
Reference

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