Embelin - CAS 550-24-3
Embelin (CAT: I004037) is a cell-permeable benzoquinone compound with notable antitumor properties. It exerts its effects by acting as an antagonist to XIAP (X-linked inhibitor of apoptosis protein), a protein that inhibits the activation of caspase-9. Embelin directly targets the Smac (second mitochondria-derived activator of caspases) and caspase-9 binding domain BIR3, thereby preventing XIAP from inhibiting caspase-9 activation. By doing so, embelin promotes caspase-9-mediated apoptosis, which is a critical mechanism for eliminating cancer cells. The ability of embelin to interfere with XIAP-mediated apoptosis inhibition highlights its potential as an anticancer therapeutic agent.
Catalog Number: I004037
CAS Number: 550-24-3
PubChem Substance ID:355039115
Molecular Formula: C17H26O4
Molecular Weight:294.4
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
Synonyms | 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione |
---|
Property
Molecular Formula: | C17H26O4 |
---|---|
Molecular Weight | 294.4 |
Target: | IAP |
Solubility | DMSO 10 mg/ml |
Purity | ≥95% |
Storage | 3 years -20C powder |
IC50 | 4.1 uM [1] |
Computed Descriptor
InChIKey | IRSFLDGTOHBADP-UHFFFAOYSA-N |
---|