Embelin- CAS 550-24-3

Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties. Specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50 = 4.1 uM in a competitive binding assay with Smac peptide).

IC50 value: 4.1 uM [1]

Target: XIAP

in vitro: Embelin induced activation of caspase-9 and embelin-induced apoptosis was prevented by caspase inhibitors [2]. Treatment with subtoxic doses of Embelin broadly sensitized malignant glioma cells to TRAIL-mediated apoptosis. Notably, human astrocytes were not significantly affected by the combined treatment consisting of Embelin and TRAIL. Combined treatment with Embelin and TRAIL augmented the activation of initiator caspases-8/-9 and effector caspases-3/-7, respectively [3].

in vivo: Embelin inhibited topical edema in the mouse ear, leading to substantial reductions in skin thickness and tissue weight, inflammatory cytokine production, neutrophil-mediated myeloperoxidase activity, and various histopathological indicators. Furthermore, embelin was effective at reducing inflammatory damage induced by chronic TPA exposure [4]. Embelin (10, 30 or 50mg/kg body weight) was administrated daily per oral route for 7days. Embelin significantly attenuated DSS-induced DAI scores and tissue MPO accumulation, which implied that it suppressed weight loss, diarrhea, gross bleeding, and the infiltrations of immune cells. Embelin administration also effectively and dose-dependently prevented shortening of colon length and enlargement of spleen size [5].

Catalog Number: I004037

CAS Number: 550-24-3

PubChem Substance ID:355039115

Molecular Formula: C17H26O4

Molecular Weight:294.4

Purity: ≥95%

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Synonym

Synonyms2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione

Property

Molecular Formula: C17H26O4
Molecular Weight294.4
Target:IAP
SolubilityDMSO 10 mg/ml
Purity≥95%
Storage3 years -20C powder
IC504.1 uM [1]

Computed Descriptor

InChIKeyIRSFLDGTOHBADP-UHFFFAOYSA-N