Embelin - CAS 550-24-3

Embelin (CAT: I004037) is a cell-permeable benzoquinone compound with notable antitumor properties. It exerts its effects by acting as an antagonist to XIAP (X-linked inhibitor of apoptosis protein), a protein that inhibits the activation of caspase-9. Embelin directly targets the Smac (second mitochondria-derived activator of caspases) and caspase-9 binding domain BIR3, thereby preventing XIAP from inhibiting caspase-9 activation. By doing so, embelin promotes caspase-9-mediated apoptosis, which is a critical mechanism for eliminating cancer cells. The ability of embelin to interfere with XIAP-mediated apoptosis inhibition highlights its potential as an anticancer therapeutic agent.

Catalog Number: I004037

CAS Number: 550-24-3

PubChem Substance ID:355039115

Molecular Formula: C17H26O4

Molecular Weight:294.4

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione

Property

Molecular Formula: C17H26O4
Molecular Weight294.4
Target:IAP
SolubilityDMSO 10 mg/ml
Purity≥95%
Storage3 years -20C powder
IC504.1 uM [1]

Computed Descriptor

InChIKeyIRSFLDGTOHBADP-UHFFFAOYSA-N