ELOVL6-IN-2

• CAT Number: I045531
• CAS Number: 1067647-43-1
• Molecular Formula: C28H23F6N3O4
• Molecular Weight: 579.49
• Purity: ≥95%
• Synonyms: 6,6-dimethyl-3-[5-methyl-3-oxo-2-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl]-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione
• InChI: InChI=1S/C28H23F6N3O4/c1-15-21(23(39)37(35-15)17-9-11-18(12-10-17)41-28(32,33)34)26(27(29,30)31)22-19(13-25(2,3)14-20(22)38)36(24(26)40)16-7-5-4-6-8-16/h4-12,35H,13-14H2,1-3H3
• InChIKey: XLEVMSDNWOWFNX-UHFFFAOYSA-N
• SMILES: CC1=C(C(=O)N(N1)C2=CC=C(C=C2)OC(F)(F)F)C3(C4=C(CC(CC4=O)(C)C)N(C3=O)C5=CC=CC=C5)C(F)(F)F

ELOVL6-IN-2 (Cat No.: I045531) is a small-molecule inhibitor of elongation of very long-chain fatty acids protein 6 (ELOVL6), an enzyme that catalyzes the elongation of saturated and monounsaturated fatty acids. By blocking ELOVL6 activity, this compound reduces the synthesis of long-chain fatty acids, influencing lipid composition, insulin sensitivity, and energy metabolism. ELOVL6-IN-2 is primarily used as a biochemical research tool to study lipid metabolic pathways and their links to metabolic disorders such as obesity, insulin resistance, type 2 diabetes, and cardiovascular disease.

Reference

[1]. akahashi T, et al. Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. J Med Chem. 2009;52(10):3142-3145.
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