eIF4E-IN-2

• CAT Number: I045157
• CAS Number: 2575840-38-7
• Molecular Formula: C37H33ClF2N8O4S2
• Molecular Weight: 791.29
• Purity: ≥95%
• Synonyms: 7-[5-chloro-2-[3-[5-cyano-6-[[1-(3,3-difluorocyclobutyl)piperidin-4-yl]-methylamino]-2-methyl-4-oxopyrido[3,4-d]pyrimidin-3-yl]prop-1-ynyl]phenyl]-N-methylsulfonylthieno[3,2-b]pyridine-3-carboxamide
• InChI: InChI=1S/C37H33ClF2N8O4S2/c1-21-44-30-19-43-34(46(2)24-9-13-47(14-10-24)25-16-37(39,40)17-25)28(18-41)31(30)36(50)48(21)12-4-5-22-6-7-23(38)15-27(22)26-8-11-42-32-29(20-53-33(26)32)35(49)45-54(3,51)52/h6-8,11,15,19-20,24-25H,9-10,12-14,16-17H2,1-3H3,(H,45,49)
• InChIKey: QYMHJCNNNOKGHG-UHFFFAOYSA-N
• SMILES: CC1=NC2=CN=C(C(=C2C(=O)N1CC#CC3=C(C=C(C=C3)Cl)C4=C5C(=NC=C4)C(=CS5)C(=O)NS(=O)(=O)C)C#N)N(C)C6CCN(CC6)C7CC(C7)(F)F

eIF4E-IN-2（Cat No.:I045157）is a potent, selective inhibitor of eukaryotic translation initiation factor 4E (eIF4E), a key regulator of cap-dependent mRNA translation. By binding to eIF4E, it disrupts the eIF4F complex formation, thereby suppressing translation of oncogenic mRNAs involved in cell proliferation and survival. eIF4E-IN-2 exhibits antiproliferative activity in various cancer cell lines and shows promise as a targeted therapeutic for malignancies driven by dysregulated protein synthesis. Its mechanism highlights the therapeutic potential of translation initiation blockade in oncology research and related biomedical studies.