EGFR Protein Tyrosine Kinase Substrate

• CAT Number: I044277
• CAS Number: 945830-38-6
• Molecular Formula: C48H73N11O17
• Molecular Weight: 1076.16
• Purity: ≥95%
• Synonyms: (2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoic acid
• InChI: InChI=1S/C48H73N11O17/c1-6-24(4)39(47(74)59-19-7-8-34(59)46(73)53-28(13-16-35(50)61)41(68)54-30(48(75)76)14-17-36(51)62)58-45(72)31(20-23(2)3)56-43(70)32(21-26-9-11-27(60)12-10-26)57-42(69)29(15-18-37(63)64)52-44(71)33(22-38(65)66)55-40(67)25(5)49/h9-12,23-25,28-34,39,60H,6-8,13-22,49H2,1-5H3,(H2,50,61)(H2,51,62)(H,52,71)(H,53,73)(H,54,68)(H,55,67)(H,56,70)(H,57,69)(H,58,72)(H,63,64)(H,65,66)(H,75,76)/t24-,25-,28-,29-,30-,31-,32-,33-,34-,39-/m0/s1
• InChIKey: LQRUFPWSECMCHG-YBFBXAKBSA-N
• SMILES: CC[C@H](C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)N

EGFR Protein Tyrosine Kinase Substrate（Cat No.:I044277）is a synthetic peptide designed to mimic the natural substrates phosphorylated by the epidermal growth factor receptor (EGFR), a transmembrane tyrosine kinase involved in regulating cell proliferation, survival, and differentiation. This substrate is commonly used in biochemical assays to measure EGFR kinase activity and screen for inhibitors. It enables precise analysis of phosphorylation kinetics and downstream signaling events. Widely utilized in cancer research, especially in studies targeting EGFR-driven tumors, the substrate supports drug discovery and mechanistic investigations of tyrosine kinase signaling pathways.