EGFR-IN-9

• CAT Number: I017895
• CAS Number: 1226549-39-8
• Molecular Formula: C29H24N4O3
• Molecular Weight: 476.53
• Purity: ≥95%
• IUPAC Name: N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]amino]-6-phenylfuro[2,3-d]pyrimidin-5-yl]phenyl]prop-2-enamide
• InChI: InChI=1S/C29H24N4O3/c1-2-24(35)32-22-15-9-14-21(16-22)25-26-28(33-23(17-34)19-10-5-3-6-11-19)30-18-31-29(26)36-27(25)20-12-7-4-8-13-20/h2-16,18,23,34H,1,17H2,(H,32,35)(H,30,31,33)/t23-/m1/s1
• InChIKey: GFTOODFOXIDLNF-HSZRJFAPSA-N
• SMILES: C=CC(=O)NC1=CC=CC(=C1)C2=C(OC3=NC=NC(=C23)N[C@H](CO)C4=CC=CC=C4)C5=CC=CC=C5

EGFR-IN-9（Cat No.:I017895）is a potent and selective small-molecule inhibitor targeting the epidermal growth factor receptor (EGFR), a key tyrosine kinase involved in tumor cell proliferation, survival, and metastasis. By blocking EGFR signaling pathways, EGFR-IN-9 suppresses oncogenic processes such as uncontrolled cell growth and resistance mechanisms. It demonstrates significant activity in preclinical studies against EGFR-driven cancers, including non-small cell lung cancer (NSCLC). With favorable selectivity, it reduces off-target interactions, making it a valuable research tool for exploring targeted cancer therapeutics and resistance pathways in oncology drug development.