EGFR-IN-8

• CAT Number: I018091
• CAS Number: 2407957-87-1
• Molecular Formula: C32H23ClF3N7O4
• Molecular Weight: 662.02
• Purity: ≥95%
• Synonyms: N-[3-chloro-4-[5-[3-[[4-(cyclopropanecarbonylamino)-3-(trifluoromethyl)phenyl]carbamoylamino]phenyl]-1,2,4-oxadiazol-3-yl]phenyl]pyridine-3-carboxamide
• InChI: InChI=1S/C32H23ClF3N7O4/c33-25-15-22(38-29(45)19-4-2-12-37-16-19)8-10-23(25)27-42-30(47-43-27)18-3-1-5-20(13-18)39-31(46)40-21-9-11-26(24(14-21)32(34,35)36)41-28(44)17-6-7-17/h1-5,8-17H,6-7H2,(H,38,45)(H,41,44)(H2,39,40,46)
• InChIKey: IIUNSVLRVWGJRM-UHFFFAOYSA-N
• SMILES: C1CC1C(=O)NC2=C(C=C(C=C2)NC(=O)NC3=CC=CC(=C3)C4=NC(=NO4)C5=C(C=C(C=C5)NC(=O)C6=CN=CC=C6)Cl)C(F)(F)F

EGFR-IN-8（Cat No.:I018091）is a potent, selective inhibitor of the epidermal growth factor receptor (EGFR), a tyrosine kinase frequently dysregulated in cancer. By targeting EGFR signaling, it effectively blocks pathways that drive tumor cell growth, survival, and metastasis. This compound is widely used in oncology research to study mechanisms of resistance, receptor mutations, and therapeutic strategies for lung, breast, and colorectal cancers. EGFR-IN-8’s strong activity and specificity make it an essential chemical probe in cancer biology, facilitating preclinical evaluation of targeted therapies and novel combination approaches.