EGFR/ErbB-2/ErbB-4 inhibitor-2

• CAT Number: R027013
• CAS Number: 179248-61-4
• Molecular Formula: C23H21N3O3
• Molecular Weight: 387.43
• Purity: ≥95%
• Synonyms: 6,7-dimethoxy-N-(4-phenylmethoxyphenyl)quinazolin-4-amine
• InChI: InChI=1S/C23H21N3O3/c1-27-21-12-19-20(13-22(21)28-2)24-15-25-23(19)26-17-8-10-18(11-9-17)29-14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,24,25,26)
• InChIKey: DNOKYISWMVFYFA-UHFFFAOYSA-N
• SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)OCC4=CC=CC=C4)OC

EGFR/ErbB-2/ErbB-4 inhibitor-2 (Cat No.: R027013) is a potent small-molecule tyrosine kinase inhibitor that selectively targets epidermal growth factor receptor (EGFR/ErbB1), HER2 (ErbB2), and HER4 (ErbB4). By blocking phosphorylation and downstream signaling through the PI3K/AKT and MAPK/ERK pathways, it suppresses cell proliferation, survival, and migration. This inhibitor is widely used in cancer research to study ErbB-driven oncogenesis, therapeutic resistance mechanisms, and receptor cross-talk. EGFR/ErbB-2/ErbB-4 inhibitor-2 provides a valuable pharmacological tool for exploring targeted therapy strategies in oncology and receptor tyrosine kinase biology.

Reference

[1]. Perry S Brignola, et al. Comparison of the biochemical and kinetic properties of the type 1 receptor tyrosine kinase intracellular domains. Demonstration of differential sensitivity to kinase inhibitors. J Biol Chem. 2002 Jan 11;277(2):1576-85.
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