For research use only. Not for therapeutic Use.
EG01377 dihydrochloride（Cat No.:I045838）is a selective inhibitor of the receptor for advanced glycation end products (RAGE). By blocking RAGE–ligand interactions, it reduces downstream signaling linked to oxidative stress, inflammation, and fibrosis. This compound is widely used in research exploring the role of RAGE in metabolic disorders, cardiovascular disease, neurodegeneration, and cancer. Through inhibition of RAGE activity, EG01377 dihydrochloride helps clarify pathways driving diabetic complications, vascular dysfunction, and chronic inflammation. It is a valuable small molecule tool for studying RAGE-mediated mechanisms in diverse disease models.
| CAS Number | 2749438-61-5 |
| Synonyms | (2S)-2-[[3-[[5-[4-(aminomethyl)phenyl]-2,3-dihydro-1-benzofuran-7-yl]sulfonylamino]thiophene-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid;dihydrochloride |
| Molecular Formula | C26H32Cl2N6O6S2 |
| Purity | ≥95% |
| IUPAC Name | (2S)-2-[[3-[[5-[4-(aminomethyl)phenyl]-2,3-dihydro-1-benzofuran-7-yl]sulfonylamino]thiophene-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid;dihydrochloride |
| InChI | InChI=1S/C26H30N6O6S2.2ClH/c27-14-15-3-5-16(6-4-15)18-12-17-7-10-38-22(17)21(13-18)40(36,37)32-19-8-11-39-23(19)24(33)31-20(25(34)35)2-1-9-30-26(28)29;;/h3-6,8,11-13,20,32H,1-2,7,9-10,14,27H2,(H,31,33)(H,34,35)(H4,28,29,30);2*1H/t20-;;/m0../s1 |
| InChIKey | ZYFLTIBQQSYBQT-FJSYBICCSA-N |
| SMILES | C1COC2=C1C=C(C=C2S(=O)(=O)NC3=C(SC=C3)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C4=CC=C(C=C4)CN.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
