Efavirenz

• CAT Number: A000012
• CAS Number: 154598-52-4
• Molecular Formula: C14H9ClF3NO2
• Molecular Weight: 315.7
• Purity: ≥95%
• Synonyms: ustiva, Stocrin, DMP-266, DMP 266
• Target: HIV
• Solubility: >15.6mg/mL in DMSO
• Storage: Store at -20C
• IUPAC Name: (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
• InChI: InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1
• InChIKey: XPOQHMRABVBWPR-UHFFFAOYSA-N
• SMILES: ClC1=CC=C2C([C@@](C#CC3CC3)(C(F)(F)F)OC(N2)=O)=C1

Efavirenz ( CAS 154598-52-4) is a non-nucleoside reverse transcriptase inhibitor, NNRTI. Efavirenz is highly specific and potent allosteric inhibitors of HIV-1 reverse transcriptase. Efavirenz also inhibits the late stages of HIV-1 replication by interfering with HIV-1 Gag-Pol polyprotein processing. It is used as part of highly active antiretroviral therapy for the treatment of a human immunodeficiency virus type 1.

Overview of Clinical Research

Efavirenz is a non-nucleoside reverse transcriptase inhibitor developed by Merck&Co. It is used to treat HIV-1 infections. 

Reference

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