For research use only. Not for therapeutic Use.
(E,E)-RGFP966(CAT: R061210) is a potent and highly selective histone deacetylase 3 (HDAC3) inhibitor with an IC₅₀ of approximately 80 nM, demonstrating over 200-fold selectivity relative to other HDAC isoforms—particularly HDAC1, 2, and 8—up to 15 µM concentrations . This brain-penetrant small molecule crosses the blood–brain barrier and modulates cortical plasticity, memory consolidation, and extinction of cocaine-seeking behavior in rodent models. It also exhibits neuroprotective, anti-inflammatory, and anti-tumor activities in preclinical studies, including reduced malignant cell proliferation, enhanced apoptosis, and suppression of NF-κB signaling. Supplied as a white to off-white solid with purity ≥ 98%, (E,E)-RGFP966 is ideal for epigenetic, neurobiology, oncology, and inflammation research.
| CAS Number | 1396841-57-8 |
| Synonyms | (E)-N-(2-amino-4-fluorophenyl)-3-[1-[(E)-3-phenylprop-2-enyl]pyrazol-4-yl]prop-2-enamide |
| Molecular Formula | C21H19FN4O |
| Purity | ≥95% |
| IUPAC Name | (E)-N-(2-amino-4-fluorophenyl)-3-[1-[(E)-3-phenylprop-2-enyl]pyrazol-4-yl]prop-2-enamide |
| InChI | InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+ |
| InChIKey | BLVQHYHDYFTPDV-VCABWLAWSA-N |
| SMILES | C1=CC=C(C=C1)C=CCN2C=C(C=N2)C=CC(=O)NC3=C(C=C(C=C3)F)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
