For research use only. Not for therapeutic Use.
Edralbrutinib (Cat No.:I026719) is an oral, reversible covalent inhibitor of Bruton’s tyrosine kinase (BTK), a critical enzyme in B-cell receptor signaling and innate immune pathways. Unlike irreversible BTK inhibitors, edralbrutinib forms a reversible covalent bond, allowing for sustained inhibition with potential for improved safety and tolerability. It has shown promise in treating autoimmune diseases such as pemphigus vulgaris and rheumatoid arthritis by reducing pathogenic B-cell activity and inflammatory responses. Edralbrutinib is currently under clinical investigation as a targeted therapy for immune-mediated disorders and B-cell malignancies.
| CAS Number | 1858206-58-2 |
| Synonyms | 4-amino-1-[(3R)-1-but-2-ynoylpyrrolidin-3-yl]-3-[4-(2,6-difluorophenoxy)phenyl]-6H-pyrrolo[2,3-d]pyridazin-7-one |
| Molecular Formula | C26H21F2N5O3 |
| Purity | ≥95% |
| IUPAC Name | 4-amino-1-[(3R)-1-but-2-ynoylpyrrolidin-3-yl]-3-[4-(2,6-difluorophenoxy)phenyl]-6H-pyrrolo[2,3-d]pyridazin-7-one |
| InChI | InChI=1S/C26H21F2N5O3/c1-2-4-21(34)32-12-11-16(13-32)33-14-18(22-23(33)26(35)31-30-25(22)29)15-7-9-17(10-8-15)36-24-19(27)5-3-6-20(24)28/h3,5-10,14,16H,11-13H2,1H3,(H2,29,30)(H,31,35)/t16-/m1/s1 |
| InChIKey | DNPOFZXZJJDQLB-MRXNPFEDSA-N |
| SMILES | CC#CC(=O)N1CC[C@H](C1)N2C=C(C3=C2C(=O)NN=C3N)C4=CC=C(C=C4)OC5=C(C=CC=C5F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
