Ecallantide TFA

• CAT Number: I040339
• Molecular Formula: C305H442N88O91S8.xC2HF3O2
• Molecular Weight: 7053.81 (free base)
• Purity: ≥95%

Ecallantide TFA(CAT: I040339) is a recombinant, 60-amino-acid protein therapeutic that functions as a potent inhibitor of plasma kallikrein, a key enzyme in the bradykinin-mediated inflammatory pathway. As the trifluoroacetate (TFA) salt, it offers enhanced stability and solubility for investigational use. By binding to and inactivating kallikrein, Ecallantide prevents excessive bradykinin formation, thereby reducing vascular leakage, edema, and pain associated with acute hereditary angioedema (HAE) attacks. It is extensively utilized in preclinical and clinical research to explore therapies for HAE and angioedema-like conditions. Supplied as a lyophilized powder with high purity, it is reconstituted and administered subcutaneously in experimental and therapeutic studies.