Ebselen oxide

• CAT Number: M127769
• CAS Number: 104473-83-8
• Molecular Formula: C13H9NO2Se
• Molecular Weight: 290.18
• Purity: ≥95%
• Synonyms: 1-oxo-2-phenyl-1λ4,2-benzoselenazol-3-one
• InChI: InChI=1S/C13H9NO2Se/c15-13-11-8-4-5-9-12(11)17(16)14(13)10-6-2-1-3-7-10/h1-9H
• InChIKey: SBTLFLABILGUMK-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2=O

Ebselen oxide (Cat No.: M127769) is the oxidized metabolite of ebselen, an organoselenium compound with notable antioxidant, anti-inflammatory, and cytoprotective properties. Like its parent compound, ebselen oxide mimics glutathione peroxidase activity, reducing reactive oxygen species and protecting cells from oxidative stress. It has been investigated in redox biology, neuroprotection, and cardiovascular research. Ebselen oxide also serves as a valuable probe for studying selenium-based therapeutics, oxidative stress pathways, and the pharmacological actions of ebselen in disease models related to inflammation and oxidative injury.

Reference

[1]. Lieberman OJ, et al. High-throughput screening using the differential radial capillary action of ligand assay identifies ebselen as an inhibitor of diguanylate cyclases. ACS Chem Biol. 2014;9(1):183-192.
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[2]. Kim SK, et al. Inhibition of Pseudomonas aeruginosa Alginate Synthesis by Ebselen Oxide and Its Analogues. ACS Infect Dis. 2021;7(6):1713-1726.
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[3]. Wang Y, et al. Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs. Drug Des Devel Ther. 2017;11:1369-1382. Published 2017 May 2.
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