For research use only. Not for therapeutic Use.
EBOV-IN-1(CAT: I040355) is a synthetic adamantane dipeptide piperazine compound that robustly inhibits Ebola virus (EBOV) entry into host cells. It targets the host Niemann–Pick C1 (NPC1) receptor by blocking its interaction with the Ebola glycoprotein (GP), preventing viral penetration. EBOV-IN-1 demonstrates potent antiviral efficacy, suppressing pseudotyped EBOV infection with an IC₅₀ of ~13 nM. Featuring a molecular weight of 573.7 Da and >98% purity, it is supplied as a white to off-white powder, optimized for research applications. EBOV-IN-1 serves as a valuable tool in virology for studying filovirus entry and evaluating therapeutic strategies in preclinical models.
| CAS Number | 1335113-30-8 |
| Synonyms | methyl 4-[[2-[[4-[2-[[2-(1-adamantyl)acetyl]amino]acetyl]piperazin-1-yl]methyl]phenoxy]methyl]benzoate |
| Molecular Formula | C34H43N3O5 |
| Purity | ≥95% |
| IUPAC Name | methyl 4-[[2-[[4-[2-[[2-(1-adamantyl)acetyl]amino]acetyl]piperazin-1-yl]methyl]phenoxy]methyl]benzoate |
| InChI | InChI=1S/C34H43N3O5/c1-41-33(40)28-8-6-24(7-9-28)23-42-30-5-3-2-4-29(30)22-36-10-12-37(13-11-36)32(39)21-35-31(38)20-34-17-25-14-26(18-34)16-27(15-25)19-34/h2-9,25-27H,10-23H2,1H3,(H,35,38) |
| InChIKey | KSISWIVDFITFKQ-UHFFFAOYSA-N |
| SMILES | COC(=O)C1=CC=C(C=C1)COC2=CC=CC=C2CN3CCN(CC3)C(=O)CNC(=O)CC45CC6CC(C4)CC(C6)C5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
