For research use only. Not for therapeutic Use.
EB-42486（Cat No.:I045209）is a potent, selective inhibitor of protein arginine methyltransferase 3 (PRMT3), an enzyme responsible for asymmetric dimethylation of arginine residues on histones and other proteins, influencing gene expression and RNA processing. By blocking PRMT3 activity, EB-42486 modulates epigenetic regulation and impacts cellular processes such as metabolism, proliferation, and differentiation. It is a valuable research tool for elucidating PRMT3’s role in transcriptional control, metabolic pathways, and disease mechanisms. EB-42486 holds therapeutic potential for cancers, metabolic disorders, and other conditions driven by aberrant arginine methylation and PRMT3 dysregulation.
| CAS Number | 2390475-81-5 |
| Synonyms | 4,5,7,7-tetramethyl-N-(3-phenyl-1H-indazol-5-yl)tetrazolo[1,5-a]pyrimidine-6-carboxamide |
| Molecular Formula | C22H22N8O |
| Purity | ≥95% |
| IUPAC Name | 4,5,7,7-tetramethyl-N-(3-phenyl-1H-indazol-5-yl)tetrazolo[1,5-a]pyrimidine-6-carboxamide |
| InChI | InChI=1S/C22H22N8O/c1-13-18(22(2,3)30-21(29(13)4)26-27-28-30)20(31)23-15-10-11-17-16(12-15)19(25-24-17)14-8-6-5-7-9-14/h5-12H,1-4H3,(H,23,31)(H,24,25) |
| InChIKey | KHSAHYKLUPESPP-UHFFFAOYSA-N |
| SMILES | CC1=C(C(N2C(=NN=N2)N1C)(C)C)C(=O)NC3=CC4=C(C=C3)NN=C4C5=CC=CC=C5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
