E7766 diammonium salt

• CAT Number: I045617
• CAS Number: 2242635-03-4
• Molecular Formula: C24H32F2N12O8P2S2
• Molecular Weight: 780.66
• Purity: ≥95%
• Synonyms: azane;(1R,3R,15E,28R,29R,30R,31R,36R,41R)-29,41-difluoro-39-hydroxy-34-sulfanyl-39-sulfanylidene-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaza-34λ5,39λ5-diphosphaoctacyclo[28.6.4.13,36.128,31.04,8.07,12.019,24.023,27]dotetraconta-5,7(12),8,10,15,19(24),20,22,25-nonaene 34-oxide
• InChI: InChI=1S/C24H26F2N10O8P2S2.2H3N/c25-13-17-11-5-39-46(38,48)44-18-12(6-40-45(37,47)43-17)42-24(14(18)26)36-10-34-16-20(30-8-32-22(16)36)28-4-2-1-3-27-19-15-21(31-7-29-19)35(9-33-15)23(13)41-11;;/h1-2,7-14,17-18,23-24H,3-6H2,(H,37,47)(H,38,48)(H,27,29,31)(H,28,30,32);2*1H3/b2-1+;;/t11-,12-,13-,14-,17-,18-,23-,24-,45?,46?;;/m1../s1
• InChIKey: HGYDKGHNNZBHIY-KHAHIFMESA-N
• SMILES: C1C=CCNC2=C3C(=NC=N2)N(C=N3)C4C(C5C(O4)COP(=O)(OC6C(COP(=S)(O5)O)OC(C6F)N7C=NC8=C(N1)N=CN=C87)S)F.N.N

E7766 diammonium salt (Cat No.: I045617) is a potent macrocyclic immunomodulator derived from a natural product scaffold, designed as a novel agonist of Toll-like receptors (TLRs) 7, 8, and 9. By activating innate immune pathways, E7766 induces cytokine production and stimulates both innate and adaptive immune responses. It has been investigated for applications in cancer immunotherapy and infectious disease treatment. The diammonium salt form enhances solubility and handling. E7766 diammonium salt serves as a valuable tool for studying TLR-mediated signaling and immunotherapeutic development.

Reference

[1]. Dae-Shik Kim, et al. E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity. ChemMedChem. 2021 Jun 7;16(11):1740-1743.
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