(E/Z)-Sivopixant

• CAT Number: I044672
• CAS Number: 1640808-39-4
• Molecular Formula: C25H22ClN5O5
• Molecular Weight: 507.93
• Purity: ≥95%
• Synonyms: (2S)-3-[3-[(4-chlorophenyl)methyl]-2,6-dioxo-4-(4-pyridin-2-yloxyanilino)-1,3,5-triazin-1-yl]-2-methylpropanoic acid
• InChI: InChI=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8-6-17)28-19-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H,32,33)(H,28,29,34)/t16-/m0/s1
• InChIKey: SKZQFKBIJUXXCG-INIZCTEOSA-N
• SMILES: C[C@@H](CN1C(=O)N=C(N(C1=O)CC2=CC=C(C=C2)Cl)NC3=CC=C(C=C3)OC4=CC=CC=N4)C(=O)O

(E/Z)-Sivopixant（Cat No.:I044672）is a selective antagonist of the P2X3 receptor, a ligand-gated ion channel involved in sensory nerve signaling and chronic cough reflex. By blocking P2X3, (E/Z)-sivopixant reduces hypersensitive cough responses without significantly affecting taste perception—a common issue with earlier P2X3 antagonists. The (E/Z) notation refers to its stereoisomeric forms, contributing to its pharmacological profile and improved tolerability. It has demonstrated efficacy in clinical trials for refractory chronic cough and other sensory-related disorders, positioning it as a promising non-opioid therapy for persistent cough management.