For research use only. Not for therapeutic Use.
(E/Z)-GSK5182（Cat No.:I045879）is a synthetic estrogen-related receptor gamma (ERRγ) inverse agonist that modulates transcriptional activity involved in energy metabolism, mitochondrial function, and cancer progression. As a stereoisomeric mixture, it binds to ERRγ and suppresses its constitutive activity, altering the expression of metabolic and proliferative genes. This compound is valuable for exploring ERRγ’s role in metabolic diseases, including diabetes, obesity, and cardiovascular disorders, as well as in cancer research. (E/Z)-GSK5182 provides a powerful tool for probing nuclear receptor biology and developing ERRγ-targeted therapeutic strategies.
| CAS Number | 2699724-40-6 |
| Synonyms | 4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-5-hydroxy-2-phenylpent-1-enyl]phenol |
| Molecular Formula | C27H31NO3 |
| Purity | ≥95% |
| IUPAC Name | 4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-5-hydroxy-2-phenylpent-1-enyl]phenol |
| InChI | InChI=1S/C27H31NO3/c1-28(2)18-20-31-25-16-12-23(13-17-25)27(22-10-14-24(30)15-11-22)26(9-6-19-29)21-7-4-3-5-8-21/h3-5,7-8,10-17,29-30H,6,9,18-20H2,1-2H3/b27-26- |
| InChIKey | ZVSFNBNLNLXEFQ-RQZHXJHFSA-N |
| SMILES | CN(C)CCOC1=CC=C(C=C1)/C(=C(/CCCO)\C2=CC=CC=C2)/C3=CC=C(C=C3)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
