For research use only. Not for therapeutic Use.
(E/Z)-E64FC26 (Cat No.: I045511) is a dual conformation small-molecule inhibitor targeting ferroptosis, a regulated form of cell death driven by lipid peroxidation. As a stereoisomeric compound, it exists in both E and Z configurations, enabling studies of structure–activity relationships in ferroptosis modulation. Researchers use (E/Z)-E64FC26 to investigate mechanisms of oxidative stress, iron-dependent lipid metabolism, and cell death pathways relevant to cancer, neurodegeneration, and inflammation. Its unique activity provides a valuable tool for exploring therapeutic strategies against ferroptosis-associated diseases and metabolic disorders.
| CAS Number | 2285446-67-3 |
| Synonyms | (1E)-1-nonylidene-3-(trifluoromethyl)indene-5,6-diol |
| Molecular Formula | C19H23F3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H23F3O2/c1-2-3-4-5-6-7-8-9-13-10-16(19(20,21)22)15-12-18(24)17(23)11-14(13)15/h9-12,23-24H,2-8H2,1H3/b13-9+ |
| InChIKey | OWYMWLCFHDHVAH-UKTHLTGXSA-N |
| SMILES | CCCCCCCCC=C1C=C(C2=CC(=C(C=C21)O)O)C(F)(F)F |
| Reference | [1]. Nathan G. Dolloff, et al. Indene derivatives and uses thereof. US20190062298A1. [2]. Robinson RM, et al. Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma. Leukemia. 2019 Apr;33(4):1011-1022. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
